ACADSTAFF UGM
| Judul/Title | Toksisitas Oral Akut Arthrospira maxima dan Chlorella vulgaris Isolat Glagah Pada Tikus (Rattus norvegicus Berkenhout, 1769) Galur Wistar (i) |
| Penulis/Author | Laksmindra Fitria, S.Si., M.Si. (1) ; TIKA CANDRA DEWI (2); KHOLIDATUS SILMI (3); Dra. Mulyati, M.Si. (4); Rahadian Yudo Hartantyo, S.Si., M.Sc. (5); Dr. Slamet Widiyanto, S.Si., M.Sc. (6); Dr. Eko Agus Suyono, S.Si., M.App.Sc. (7) |
| Tanggal/Date | 2 2022 |
| Kata Kunci/Keyword | |
| Abstrak/Abstract | Arthrospira (Spirulina) and Chlorella are microalgae that possess benefits for health, therefore they are developed as food supplement products. This study aimed to study the toxicity and the safety of consuming A.maxima and C.vulgaris isolated from Glagah coastal water at D.I. Yogyakarta Province using Wistar rats as preclinical model. Toxicity studies are the first step before exploring the potential, utilization and processing these microalgae as health supplement products. Toxicity test procedure following OECD Guideline No. 420. Parameters observed included: body weight, hematological profile, and evaluation of liver function (ALT activity and bilirubin level) and renal function (creatinine and uric acid levels). Based on the results, it can be concluded that oral administration of A.maxima and C.vulgaris up to dose of 5000 mg/kg bw demonstrated no signs of toxicity, indicated by values for most of variables were within normal range. Fluctuation in values were manifestation of normal physiological dynamic. In this study we found that C.vulgaris could be a potential antianemia. Since this toxicity study is a single-dose and limited to acute period, it is suggested to continue with repeated-dose toxicity studies and longer periods to study the toxicity and the safety, as well as to explore this potential. |
| Rumpun Ilmu | Biologi (dan Bioteknologi Umum) |
| Bahasa Asli/Original Language | Bahasa Indonesia |
| Level | Nasional |
| Status |