The Roles of Strontium Ions in Regenerative Dentistry: Cells Interaction, Mechanism of Action, and Future Perspective
Penulis/Author
ALDI HERBANU (1); Prof. drg. Ika Dewi Ana, M.Kes., Ph.D. (2); Dr. drg. Retno Ardhani, M.Sc. (3); Prof. Dr. drg. Widowati Siswomihardjo, M.S. (4)
Tanggal/Date
8 2021
Kata Kunci/Keyword
Abstrak/Abstract
Strontium (Sr) ions play as a key role in the regeneration of hard tissues such as bones and
teeth. Regarding the role of Sr ions in the human body, many studies have been conducted,
which may be applied to hard tissue regeneration and regeneration in dentistry. In the
mechanism of bone remodelling, Sr ions have a dual effect on bone metabolism: inhibit bone
absorption and stimulate bone formation. From the chemical point of view, substitution of
Calcium (Ca) ions with Sr in the hydroxyapatite (HA) structure will decrease its crystallinity,
thus influence bone resorption process. In dentistry, diffusion of additional Sr ions from
dental restorative material has also been known to have an important impact on permanent
dentin in the body. In this study, 191 titles from MEDLINE (PubMed) databases and 15 titles
from the Scopus database were screened to meet the relevant topic of the study. From the
included studies, it was confirmed that Sr ions seem to enhance the bone quality around the
implant and the osseointegration of the implant. The unique dual mode of action of Sr ion has
two possible mechanisms. They balance bone renewal by activating Ca (or other cations)
sensing receptors and increasing the expression of osteoprotegerin (OPG) and reducing the
expression of RANK ligand by osteoblast. In various compromised cases such as patient with
osteoporosis, Sr-substituted scaffold can be an option when regenerative dental therapy is
needed. Further investigation is needed to fully understand the role of Sr ions in regenerative
pathways and its cellular mechanism to result better choices in regenerative therapy.
Rumpun Ilmu
Bidang Ilmu Kedokteran Gigi Lain Yang Belum Tercantum
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
The Roles of Strontium Ions in Regenerative Dentistry.pdf
[PAK] Full Dokumen
2
Akreditasi Annals of the Romanian Society for Cell Biology.pdf
3
42_ Similaritas The Roles of Strontium Ions in Regenerative Dentistry.pdf
[PAK] Cek Similarity
4
Bukti Korespondensi Annals of the Romanian Society for Cell Biology - 2021.pdf
[PAK] Bukti Korespondensi Penulis
5
form-L1L2L3-permohonan_penghargaan-karya-ilmiah-sudah-terbit-2021-ID Ana - ARSCB.pdf
6
Tautan Google Scholar Article.pdf
7
The Roles of Strontium Ions in Regenerative Dentistry_ Cells Interaction, Mechanism of Action, and Future Perspective (1).pdf
