| Abstrak/Abstract |
Interindividual different in response toward drugs has been reported since 5
decades ago. Since then, s tudies about genetic varia tion that responsible for this
di ffer response growth fas tly. Receptors , channels, metaboli zing enzymes,
transporters has been known to affected by this polymorphisms. Wi thin these,
metabolizing enzymes (phase I and phase II ) is one of the mos t important a rea to
s tudy. It is reported that in the metaboli zing enzyme family, cytochrome P450
(CYP450) is responsible for 70-80% of phase I dependent metabolism. and is
mediate for almos t 50% of the overall elimination of commonly used drugs . Thi
family of enzyme metaboli ze large type of drug. Even thought i ts is attract many of
research group across the globe, the data of CYP polymorphism in Indonesian
population is very limi ted. Most of genetic polymorphism s tudies in Indonesian
population mainly were done in a rea of malaria or phase II metabolizing enzyme.
However, there are some reports about the polymorphism of CYP450 in Indonesian
population even though those s tudies not mainly focus on the genetic
polymorphism comparison of CYP450 gene between Indonesian ethnics . The role o
the genetic polymorphism in this enzyme for clinical pharmacy practice is
dis cussed. |
