| Abstrak/Abstract |
Background It has been reported that dietary inulin was able to modulate glucagon like peptide-1 (GLP-1). This study was aimed to examine the effect of lesser yam based cookies on fasting plasma GLP-1, blood glucose, lipid profile, appetite and dietary intake in overweight and obese individuals. Methods This was an experimental study on overweight or obese adults aged 21-50 years old. The intervention was done by giving 87 gram of cookies made with lesser yam flour for 6 weeks. Anthropometric measures, appetite, dietary inatake, fasting plasma glucose, lipid and GLP-1 concentrations were measured before and after the intervention. Results A total of 16 overweight/obese individuals finished this study. After the intervention, there were no changes in anthropometric measurements and fasting glucose level after the intervention (p>0,05). Plasma LDL and total cholesterol were reduced after the intervention (p=0,033 and p=0,035, respectively). Although fasting GLP-1 level (p=0,121) was unchanged, we showed that changes in GLP-1 concentration was associated with changes in LDL and total cholesterol (p=0,002 and p=0,001, respectively). After the intervention the dietary intake includes total energy (p=0,013), protein (p=0, 004) and carbohydrate (p=0,02) were significantly reduced. Based on paired t-test that was done in each time point, after the intervention subjects had lower hunger feeling and higher satiety especially at 4 (p=0,039) and 3 (p=0,039) hours after breakfast, respectively. Conclusion The lesser yam based cookies reduced fasting plasma LDL and total cholesterol but not glucose and GLP-1 level after 6 weeks of intervention. Additionally, the intervention was also reduced hunger and increased fullness thus reduced dietary intake. |
