THE POTENTIAL OF SNAIL (Achatina fulica) MUCUS GEL AS A PHYTHOPHARMACA TO ACCELERATE THE INFLAMATION PROCESS IN WOUND HEALING
Penulis/Author
drg. Yosaphat Bayu Rosanto, MDSc., Sp.BMM., Subsp.IDM(K) (1); drg. Cahya Yustisia Hasan, Sp.BM. (2); drg. Rahardjo, S.U., Sp.BM. (3); ANTONIUS SURYA S P (4)
Tanggal/Date
11 2022
Kata Kunci/Keyword
Abstrak/Abstract
Aim: to determine the potential of snail (Achatina fulica) mucus gel as a phytopharmaca material that can accelerate the inflammatory process in wound healing
Materials and Methods: The research was carried out by taking snail mucus gel and making it in a gel preparation with CMC-Na 3%. Snail mucus gel was prepared in concentrations of 0% (control), 24%, 48%, and 96%. Six Wistar rats were made 4 pieces of 5mm diameter punch biopsy excision wound on the back skin of the Wistar rat. Snail mucus gel was applied to the back wounds of mice. The mice were euthanized on days 2, 4, and 7 and the skin wound area was prepared with eosin hematoxylin preparations. The number of polymorphonuclear leukocytes was observed in the process of wound healing in the dermis by observation under a binocular microscope with a magnification of 400x.
Result: Significant difference in the number of polymorphonuclear leukocytes (p = 0.000) with the two-way ANOVA statistical test. The increase in the number of polymorphonuclear leukocytes reached its peak on day 4 on 48% and 96% application of snail mucus gel. Snail mucus gel 96% showed a significant number of polymorphonuclear leukocytes compared to other concentrations with the post hoc test with Tukey's test.
Conclusion: Snail mucus content can accelerate the inflammatory process in wound healing.
