| Abstrak/Abstract |
Breath analysis is useful for the diagnosis of human diseases and monitoring of
metabolic status. However, because of the low concentrations and the large numbers of
compounds in the breath, the breath analysis requires highly sensitive and highly selective
instruments to identify and determine the concentrations of certain biomarkers [1]. Various
methods developed over the past 20 years to detect biomarker gases [2]. CO2 laser
photoacoustic spectroscopy offers a sensitive technique for the detection and monitoring of gas
footprints at low concentrations [3]. The performance of photoacoustic spectrometer (PAS)
examined with intracavity configuration. In this research, the highest observed intracavity
power was (49,96 ? 0,02) W for active medium gas composition He: N2: CO2 at 30:50:50. The
highest laser absorption line for standard acetone gas set at 10P20, and the lowest detection
limit set at (30 ? 4) ppb. For application purposes, the photoacoustic spectrometer was used to
measure the concentration of acetone gas in exhaled gases from a group of patients with type 2
diabetes mellitus and a group of healthy volunteers. Exhaled gas sampling method took
manually, and the measurement result was examined using multicomponent analysis. The
measurement showed that the highest acetone gas concentration for type 2 diabetes mellitus
patients was (162 ? 3) 10 ppb and the lowest one was (101 ? 3) 10 ppb. Furthermore, for
healthy volunteers, the highest acetone gas concentration was (85 ? 3) 10 ppb and the lowest
one was (15 ? 3) 10 ppb. |
