Karya
Judul/Title The impact of medial temporal and parietal atrophy on cognitive function in dementia
Penulis/Author Noor Alia Susianti (1); Dr. dr. Astuti, Sp.S(K) (2); dr. Amelia Nur Vidyanti, Sp.S(K), Ph.D (3) ; dr. Indarwati Setyaningsih, Sp.S (K) (4); Dr. dr. Abdul Gofir, Sp.S(K)., M.Sc. (5); Dr. dr. Cempaka Thursina Srie Setyaningrum, Sp.S(K) (6); Prof. Dr. Christantie Effendy, S.Kp., M.Kes. (7); dr. Nurhuda Hendra Setyawan., Sp.Rad (8); Prof. Dr. dr. Ismail Setyopranoto, Sp.S(K) (9)
Tanggal/Date 2024
Kata Kunci/Keyword
Abstrak/Abstract Although medial temporal atrophy (MTA) and parietal atrophy (Koedam score) have been used to diagnose Alzheimer's disease (AD), early detection of other dementia types remains elusive. The study aims to investigate the association between these brain imaging markers and cognitive function in dementia. This cross-sectional study collected data from the Memory Clinic of Dr. Sardjito General Hospital Yogyakarta, Indonesia from January 2020 until December 2022. The cut-off value of MTA and Koedam score was set with Receiver Operating Curve. Multivariate analysis was performed to investigate the association between MTA and Koedam score with cognitive function. Of 61 patients, 22.95% had probable AD, 59.01% vascular dementia, and 18.03% mixed dementia. Correlation test showed that MTA and Koedam score were negatively associated with Montreal Cognitive Assessment-Indonesian Version (MoCA-INA) score. MTA score ≥ 3 (AUC 0.69) and Koedam score ≥ 2 (AUC 0.67) were independently associated with higher risk of poor cognitive function (OR 13.54, 95% CI 1.77-103.43, p = 0.01 and OR 5.52, 95% CI 1.08-28.19, p = 0.04). Higher MTA and Koedam score indicate worse cognitive function in dementia. Future study is needed to delineate these findings as prognostic markers of dementia severity. Keywords: Cognitive function; Dementia; Imaging marker; Koedam score; Medial temporal atrophy (MTA).
Rumpun Ilmu Neurologi
Bahasa Asli/Original Language English
Level Internasional
Status
Dokumen Karya
No Judul Tipe Dokumen Aksi
1cek similarity _ The impact of medial temporal and parietal atrophy on cognitive function in dementia.pdf[PAK] Cek Similarity
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