Karya
Judul/Title The effects of light and moderate intensity exercise on the femoral bone and cerebellum of d-galactose-exposed rats
Penulis/Author Prof. dr. Ginus Partadiredja, M.Sc, Ph.D. (1) ; NISA KARIMA (2); KURNIA PUTRI UTAMI (3); Prof. Dr. dr. Denny Agustiningsih, M.Kes., AIFM. (4); Dr. dr. Zaenal Muttaqien, AIFM. (5)
Tanggal/Date 19 2019
Kata Kunci/Keyword
Abstrak/Abstract Ageing causes the degeneration of organs of the locomotor system, including the cerebellum and bones. Exercise may reverse this deterioration. D-galactose has been frequently used in rodents to accelerate ageing. The present study aimed at investigating the effects of exercise on cerebellar and serum growth factors, motor activity, and the number of bone cells of the femoral head of D-galactose-treated rats. Twenty-four male Wistar rats were divided randomly into four groups, i.e. three treated groups injected with 300 mg/ml/kg bw D-galactose solution daily for 4 weeks, and a control group injected with normal saline. Following the 4-week administration of D-galactose solution, two of the treated groups performed light- (45% VO2max) and moderate- (55% VO2max) intensity exercise, by running on a treadmill 4x a week for 4 weeks. Locomotor activity was examined in rotarod and open field tests. The cerebellar and serum Insulin-like Growth Factor 1 (IGF-1) and Brain Derived Neurotrophic Factor (BDNF) levels were measured using ELISA. The number of osteoblasts and osteoclasts of femoral head were estimated using unbiased stereological methods. It was found that the number of osteoclasts was higher in the D-galactose-treated group than the normal control and moderate-intensity exercise groups. No significant difference between groups was found in the rotarod and open field tests performance, IGF-1 and BDNF levels, as well as number of osteoblasts. In conclusion, a four-week administration of high dose D-galactose caused the increase of the number of osteoclasts. A subsequent four-week moderate-intensity exercise reversed this increase to the normal level.
Rumpun Ilmu Ilmu Kedokteran Dasar & Biomedis
Bahasa Asli/Original Language English
Level Internasional
Status
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