| Abstrak/Abstract |
INTRODUCTIONː microRNA (miRNA) are non-coding RNA that regulate gene expression by suppressing or degrading the target genes. miRNA downregulation or upregulation is found in a variety of diseases. Besides disease, exercise training also influences the miRNAs level. It is well-known that aerobic exercise training also triggers various phenotypic changes related to the prevention of numerous diseases. However, the mechanism is unclear. This study aimed to systematically collect information about the effects of aerobic exercises on plasma miRNAs levels, as basic information to predict the mechanism of aerobic exercise in preventing and controlling various chronic diseases through miRNA modification.
EVIDENCE ACQUISITIONː We conducted a systematic review from the Cochrane, PubMed, SAGE, and EBSCO with keywords related to “exercise”, “training”, and “miR”.
EVIDENCE SYNTHESISː Acute aerobic exercise increases miR-1, miR-133a, miR-206, miR-208b, miR-499, miR-126, and miR-146. The miRNAs change response seemed to be influenced by the exercise intensity (miR-1), exercise duration (miR-133a, 146a), exercise mode (miR-1, miR-133a), and subject’s fitness level (miR-1, miR-21).
CONCLUSIONSː The role of exercise in preventing and controlling various chronic diseases may occur through the pulsatile increase of various miRNAs which have a role as tumor suppressor genes (miR-1, miR-133a, miR-206), anti-inflammatory agents (miR-126, miR-146a) and angiogenesis regulator (miR-126). |
