Karya
Judul/Title THE EFFECT OF VARIATION CONCENTRATION OF THPGV-0 IN LOTION AND EMULGEL FORMULA TOWARD ACUTE DERMAL IRRITATION STUDY
Penulis/Author Prof. Dr. Ritmaleni,S.Si. (1) ; DINA SUCI SUSILO P (2); TIA WULANDARI (3); Prof. Dr. Drs. Abdul Karim Zulkarnain, M.Si., Apt. (4); Dr. Mimiek Murrukmihadi, S.U., Apt. (5)
Tanggal/Date 2021
Kata Kunci/Keyword
Abstrak/Abstract THPGV-0 (Tetrahydropentagamavunon-0) is a curcumin metabolite analog which known have a higher antioxidant activity than vitamin E. This compound has been formulated in lotion as anti-aging cosmetics, but the irritation effect is unknown yet. This study aims to analyze the effect of variation of THPGV-0 concentration in lotion and emulgel formula toward acute dermal irritation. The concentrations of THPGV-0 varied to 0.1 %, 0.2 %, and 0.4 % in lotion/emulgel and tested for their physical properties such as organoleptic, homogeneity, pH, spreadability, and adhesion. Acute dermal irritation test is done in accordance to In Vivo Non-Clinical Toxicity Test Guidelines by Indonesian FDA (BPOM). This study showed that Primary Irritation Index (PII) value concentrations of 0.1 %, 0.2 % and 0.4 % THPGV-0 in lotion formula are 0.014; 0.014 and 0.028 (close to 0) and in emulgel formula are 0.08 at concentration of 0.1%; 0.33 at concentration of 0.2% and 0.25 at concentration of 0.4%. PII of 0.1 %, 0.2 % and 0.4 % THPGV-0 in lotion and emulgel are included in negligible irritation response. From this study it was concluded that lotion and emulgel formula of THPGV-0 are safe due to no irritation was seen during the study.
Rumpun Ilmu Analisis Farmasi dan Kimia Medisinal
Bahasa Asli/Original Language English
Level Internasional
Status
Dokumen Karya
No Judul Tipe Dokumen Aksi
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2THE EFFECT OF VARIATION CONCENTRATION OF THPGV-0 IN LOTION AND EMULGEL TOWARD ACUTE DERMAL IRRITATION STUDY.pdf[PAK] Cek Similarity
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