Karya
Judul/Title The Effect of Oral Sildenal Therapy on HealthRelated Quality of Life in Adults with Pulmonary Arterial Hypertension related to Uncorrected Secundum Atrial Septal Defect: A Quasi Experimental Study
Penulis/Author dr. Fera Hidayati, Sp.JP. (1) ; Dr. Med. dr. Putrika Prastuti Ratna Gharini, Sp.JP(K) (2); dr. Anggoro Budi Hartopo, Sp.PD., M.Sc., Sp.JP., Ph.D (3); dr. Dyah Wulan Anggrahini, Ph.D., Sp.JP. (4); Prof. Dr. dr. Lucia Kris Dinarti, Sp.PD., Sp.JP(K). (5)
Tanggal/Date 14 2020
Kata Kunci/Keyword
Abstrak/Abstract Background: Assessment of health-related quality of life (HRQoL) are often measured as an important patient-reported outcome (PRO) in clinical studies. Pulmonary arterial hypertension (PAH) is a common complication of atrial septal defect (ASD). This study aimed to compare the HRQoL of PAH related uncorrected secundum ASD at pre and post therapy with oral sildenal therapy. Methods: We conducted quasi experimental study at Sardjito General Hospital Yogyakarta since April 2016 to August 2017. Adults with PAH related uncorrected secundum ASD, listed on Congenital Heart Disease and Pulmonary Hypertension (COHARD-PH) registry, and met the inclusion and exclusion criteria were recruited as subject. Interview was done at pre and 12 weeks post oral sildenal therapy 3 x 20 mg using the EQ-5D-3L questionnaire. Statistical analysis was done using Wilcoxon test and paired T-test to determine the differences of EQ5D utility and EQVAS score at pre and post therapy. Results: A total of 18 adult patients with PAH related to uncorrected secundum ASD were enrolled in this study (83.33?male; mean age 38.72 ± 10.81 years old). The most frequent reported problems pre therapy were pain/discomfort (83%) and anxiety/depression (78%). Wilcoxon test showed the median of EQ5D utility score were increased after sildenal therapy (before= 0.604, after=0.664; Z= -2,703; p:0.007), respectively. Meanwhile, the paired T-test results showed an increase of EQ-VAS mean difference 6.67±8.75 (p:0.005; 95% CI 2.32-11.02) after sildenal therapy. Conclusion: The administration of oral sildenal therapy 3 x 20 mg during 12 weeks in adult patients with PAH related uncorrected secundum ASD gives better HRQoL.
Rumpun Ilmu Bidang Kedokteran Spesialis Lain Yang Tercantum
Bahasa Asli/Original Language English
Level Internasional
Status
Dokumen Karya
No Judul Tipe Dokumen Aksi
1jurnal dr Fera PAK.pdf[PAK] Full Dokumen
2Hasil cek similarity - The Effect of Oral Sildenafil.pdf[PAK] Cek Similarity
3Universitas Gadjah Mada Mail - Fwd_ Decision has been reached on your submission to Health and Quality of Life Outcomes - HQLO-D-20-00038R2.pdf[PAK] Bukti Korespondensi Penulis