| Penulis/Author |
RICKY WIBOWO (1); drg. Sri Pramestri Lastianny, M.S., Sp.Perio(K). (2); Dr. drg. Retno Ardhani, M.Sc. (3); Prof. Dr. drg. Juni Handajani, M.Kes., Ph.D (4); Prof. Dr. drg. Ahmad Syaify, Sp.Perio(K) (5) |
| Abstrak/Abstract |
Introduction: The criteria for a good dental material could penetrate optimally and have biocompatibility, chemical stability, and biodegradability. Carbonated apatite-gelatin film as a Drug Delivery System (DDS) is known to increase
the effectiveness of metronidazole in the healing process of periodontal therapy. The aim of this study was to determine the effect of carbonated apatite-gelatin film adjunction as a metronidazole delivery system in cases chronic
periodontitis of post-curettage using several clinical parameters. Evaluation is carried out through measurements of Relative Attachment Loss (RAL), Pocket Depth (PD), and Bleeding on Probing (BOP). Materials and methods:
Subjects were from 45 chronic periodontitis patients who had periodontal pockets 3-5 mm depth at the Academic Dental Hospital UGM. Subjects were treated with initial scaling and root planing treatment as well as periodontal
therapy in the form of curettage. Subjects were divided into 3 groups, namely CHA film, adjuvant metronidazole, and CHA-metronidazole film. Clinical evaluations were carried out on the 0th, 7th, 21st, and 28th days. Clinical
parameters were evaluated RAL, PD, and BOP then analyzed using the Kruskal Wallis and Mann-Whitney tests. Results: Administering carbonated apatite-gelatin film as a delivery system for metronidazole in the healing of post-curettage
chronic periodontitis obtained a higher reduction in RAL, PD, and BOP values compared to administering metronidazole itself. Conclusion: TAdministering carbonated apatite-gelatin film as a metronidazole delivery system
has a higher effect of reducing RAL, PD, and BOP compared to metronidazole in healing chronic periodontitis post curettage. |
