The combination of simplex lattice design and chemometrics in the formulation of green tea leaves as transdermal matrix patch
Penulis/Author
EKA INDRA SETYAWAN (1); Prof. Dr. Abdul Rohman, S.F., M.Si., Apt. (2); Prof. Dr. apt. Erna Prawita Setyowati, M.Si. (3); Prof. Dr. apt. Akhmad Kharis Nugroho, S.Si., M.Si. (4)
Tanggal/Date
10 2021
Kata Kunci/Keyword
Abstrak/Abstract
Aim: This study was aimed to formulate a transdermal matrix patch using green tea leaf extract.
Materials and methods: The transdermal matrix patch formulation was optimized by the simplex lattice design method. The cor- relation between responses was analyzed using chemometrics. The observed responses were: 1. the physical properties of the matrix patch, and 2. the percentage of dissolution efficiency of catechins, caffeine, and epigallocatechin gallate released from the patch. The determination of drug release kinetics was based on the curve-fitting analysis using zero-order, first-order, Higuchi, and Korsmey- er-Peppas models.
Results: The results showed that the optimal formula was obtained using the mixture of HPMC K100, HPMC K4M, and PEG 400 at a ratio of 4.0: 4.5: 0.5. The principal component analysis (PCA) showed that ?300 values of catechin caffeine and epigallocatechin gallate positively correlate. A similar condition was observed between the weight and thickness of the matrix. Drug release kinetics follows the Korsmeyer-Peppas model
