Karya
Judul/Title The biofilm eradication activity of c-10 massoialactone against staphylococcus aureus
Penulis/Author HASYRUL HAMZAH (1) ; Prof. Dr.rer.nat. apt. Triana Hertiani, S.Si., M.Si. (2); Dr. Sylvia Utami Tunjung Pratiwi, S.Si., M.Si. (3); Prof. dr. Titik Nuryastuti, M.Si., Ph.D., Sp.MK(K). (4)
Tanggal/Date 2020
Kata Kunci/Keyword
Abstrak/Abstract C-10 massoaialactone is a major component of stem bark essential oils Massoia aromatica Becc, which has potential as antibacterial and antifungal but antibiofilm activity against S. aureus has never been reported. The discovery of anti-biofilm drug candidates is needed to overcome infections associated with biofilms. This study aims to determine the eradication activity of C-10 massoialactone against S. aureus biofilms. Antibacterial testing and eradication activity of S. aureus biofilms was determined using the microtiter broth method. The effectiveness of C-10 massoilactone against S. aureus biofilm was analyzed by calculating the value of minimum biofilm eradication concentration. The mechanism of action of C-10 massoilactone against S. aureus biofilms was tested using scanning electron microscopy (SEM). C-10 massoilactone 1% gives antibacterial activity of 86.80% ± 0.01 and can eradication S. aureus biofilm by 68.98% ± 0.01 and not much different from the eradication activity of chloramphenicol drug control. The results also provide evidence that C-10 masoaialactone can damage the extracellular polymeric substance (EPS) matrix and S. aureus biofilm morphology. Therefore, C-10 masoaialactone is very potential to be developed as a candidate for a new antibiofilm drug against S. aureus biofilm.
Rumpun Ilmu Biologi Farmasi
Bahasa Asli/Original Language English
Level Internasional
Status
Dokumen Karya
No Judul Tipe Dokumen Aksi
1IJPRS_2020_11_4_full dokumen.pdf[PAK] Full Dokumen
2The bio?ilm eradication activity of C-10 massoialactone against Staphylococcus aureus.pdf[PAK] Cek Similarity
3The biofilm eradication activity of c-10 massoialactone against Staphylococcus aureus (1).pdf[PAK] Full Dokumen
4The biofilm eradication activity.pdf[PAK] Full Dokumen