| Abstrak/Abstract |
Protein deficiency is known to cause significant histological changes in the heart, such as hypertrophy, left ventricular wall thickening, increase of extracellular matrix deposition and cardiomyocyte diameter, and interstitial fibrosis. Bambara groundnut (Vigna subterranea), with protein and several amino acids, has the potential to overcome protein deficiency and repair the histological changes in the heart. This research aims to study the effect of 10% protein deficiency and adding bambara groundnut on the histological structure of Swiss-Webster female mice’s hearts. Fifteen hearts from 5 groups were collected to be prepared with the paraffin method with 6 μm thickness and stained with Hematoxylin-Eosin and Mallory Acid Fuchsin. The data in this research are biometric parameters, cardiomyocyte width, left ventricular internal dimension (LVID), left ventricular posterior wall (LVPW) thickness, and the histological structure of the heart muscle. The quantitative data were analyzed with one-way ANOVA and post hoc multiple comparisons (p-value=0.05), whereas the qualitative data were analyzed using Kruskal Wallis (p<0>0.05) between the control and treatment groups on the biometric parameter, LVID, LVPW, and cardiomyocyte width. In the histological structure of heart muscle, the protein deficiency group shows alteration such as atrophy, hypertrophy, necrosis, and fibrosis lesions that are higher than the group with the addition of bambara groundnut. Therefore, adding bambara groundnut has the potential as a protein supplement to repair the histological structure of the heart with protein deficiency. |
