ACADSTAFF UGM
| Judul/Title | SYNTHESIS AND PRELIMINARY EVALUATION OF SEVERAL CHALCONE DERIVATIVES AS SUNSCREEN COMPOUNDS |
| Penulis/Author | Prof. Drs. Jumina, Ph.D. (1) ; RIZKY WORO STYANINGRUM (2); Prof. Drs. Dwi Siswanta, M.Eng., Ph.D. (3); Sugeng Triono, S.Si., M.Si. (4); YOGA PRIASTOMO (5); HARIZAL (6); Prof Dr.dr. Eti Nurwening Sholikhah, M.Kes. (7); Prof. Dr. Drs. Abdul Karim Zulkarnain, M.Si., Apt. (8) |
| Tanggal/Date | 28 2019 |
| Kata Kunci/Keyword | |
| Abstrak/Abstract | Four chalcone derivatives containing chloro and methoxy substituents were synthesized and pre-evaluated as broad-spectrum UV protector with intrinsic antioxidant activity. UV absorbance of chalcones 1-4 showed a wide range of UV absorbance values in UVB and UVA regions (?max= 310-360 nm) and molar absorptivity values (?= 14,000-20,000 M-1cm-1). Chalcones 3 and 4 showed better photostability than chalcones 1 and 2 because the lowering of their absorbance was smaller and slower under UVB irradiation. A combination of the spectra of chalcone derivatives 1-4 indicated that a formulation containing all four will provide a broad-spectrum sunscreen protecting the skin from UVA and UVB. |
| Rumpun Ilmu | Kimia |
| Bahasa Asli/Original Language | English |
| Level | Internasional |
| Status |