Karya
Judul/Title Synthesis and In Vitro Assay of Hydroxyxanthones As Antioxidant and Anticancer Agents
Penulis/Author NELA FATMASARI (1); YEHEZKIEL STEVEN KURNIAWAN (2); Prof. Drs. Jumina, Ph.D. (3) ; Prof. Dr. Chairil Anwar (4); YOGA PRIASTOMO (5); Prof. Dr.rer.nat. Harno Dwi Pranowo, M.Si. (6); Prof. Dr. Drs. Abdul Karim Zulkarnain, M.Si., Apt. (7); Prof Dr.dr. Eti Nurwening Sholikhah, M.Kes. (8)
Tanggal/Date 20 2022
Kata Kunci/Keyword
Abstrak/Abstract In the present work, three hydroxyxanthones were synthesized in 11.15–33.42% yield from 2,6-dihydroxybenzoic acid as the starting material. The chemical structures of prepared hydroxyxanthones have been elucidated by using spectroscopic techniques. Afterward, the hydroxyxanthones were evaluated as antioxidant agents through radical scavenging assay; and anticancer agents through in vitro assays against WiDr, MCF-7, and HeLa cancer cell lines. Hydroxyxanthone 3b was categorized as a strong antioxidant agent (IC50 = 349 ± 68 µM), while the other compounds were categorized as moderate antioxidant agents (IC50 > 500 µM). On the other hand, hydroxyxanthone 3a exhibited the highest anticancer activity (IC50 = 184 ± 15 µM) and the highest selectivity (SI = 18.42) against MCF-7 cancer cells. From the molecular docking study, it was found that hydroxyxanthone 3a interacted with the active sites of Topoisomerase II protein through Hydrogen bonding with DG13 and π–π stacking interactions with DA12 and DC8. These fndings revealed that hydroxyxanthones are potential candidates to be developed as antioxidant and anticancer agents in the future.
Rumpun Ilmu Kimia
Bahasa Asli/Original Language English
Level Internasional
Status
Dokumen Karya
No Judul Tipe Dokumen Aksi
1PUBLISHED Fatmasari_et_al-2022-Scientific_Reports.pdfBukti Published
2Form-L1-Synthesis and In vitro Assay of Hydroxyxanthones as Antioxidant and Anticancer Agents.pdfDokumen Pendukung Karya Ilmiah (Hibah, Publikasi, Penelitian, Pengabdian)
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