Synthesis and Antioxidant Activityof Some Dibenzylidene-Cyclohexanones
Penulis/Author
Prof. Dr. Ritmaleni,S.Si. (1); BAIQ RISMA F (2); SHINTA DIVA EKANANDA (3); BHAGASKARA NAUFAL T (4); NANDA KURNIA ARSANI (5); apt. Rumiyati, S.Si., M.Si., Ph.D. (6)
Tanggal/Date
2023
Kata Kunci/Keyword
Abstrak/Abstract
Dibenzylidene-cyclohexanone is a curcumin analog, whose activity indicates antioxidative properties. This research aims to synthesize dibenzylidene-cyclohexanone compounds and to study their antioxidant activity. The synthesis was carried out according to the carbonyl condensation reaction, and the antioxidant activity was tested using the DPPH radical scavenging activity and FRAP assay. Compound entry 1 (2,6-bis-(3’-bromo-4’-methoxybenzylidene)-cyclohexanone) and entry 3 (2,6-bis-(2’-chloro-6’-fluorobenzylidene)-cyclohexanone) were obtained in 70% yield. Following the DPPH method, compound entries 1 and 2 have the IC50values of 1565 μM and 1560 μM respectively. The values are not good enough if they are compared with vitamin E. Among the series, compound entry 1 has the best antioxidant activity via FRAP method with the IC50value of 1486 μM.
Rumpun Ilmu
Analisis Farmasi dan Kimia Medisinal
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
4537-Article Text-35455-1-10-20230328.pdf
[PAK] Full Dokumen
2
Synthesis and Antioxidant Activity of Some Dibenzylidene-Cyclohexanones _ Indonesian Journal of Pharmacy.pdf
[PAK] Full Dokumen
3
Synthesis and Antioxidant Activity of Some DibenzylideneCyclohexanones (1).pdf
