| Abstrak/Abstract |
An antibacterial compound, 1-monocaprin, has been successfully synthesized through a reaction pathway that involved the use of protected glycerol compound, 1,2-acetonide glycerol. It was found that 1,2-acetonide glycerol could be obtained through a reaction between glycerol and acetone with the use of para-toluene sulfonic acid as an acidic catalyst with 99.07% purity. A transesterification reaction without solvent between 1,2-acetonide glycerol and ethyl caprate with mole ratio of 8, using a base catalyst Na2CO3 was able to produce 1,2-acetonide-3-capryl glycerol. The product of this reaction was in the form of yellow viscous liquid with 87% purity. Deprotection reaction of 1,2-acetonide-3-capryl glycerol with Amberlyst-15 in ethanol, followed by a purification step by using a preparative thin layer chromatography can result in the production of 100% white solid 1-monocaprin. Further study showed that 1-monocaprin compound was capable of inhibiting the growth of Bacillus cereus, Salmonella thypimurium and Escherichia coli bacteria at a concentration of 1000 ?g/mL and Staphylococus aureus at a concentration of 500 ?g/mL. © 2016, Global Research Online. All rights reserved. |
