Karya
Judul/Title Subchronic Dermal Toxicity Study of Tithonia diversifolia (Hemsley) A. Gray Gel Formulation in Wistar rats
Penulis/Author MUFLIHAH RIZKAWATI (1); Prof. Dr. Mae Sri Hartati Wahyuningsih, Apt., M.Si. (2) ; Dr. dr. Setyo Purwono, M.Kes.Sp.PD (3); dr. Dwi Aris Agung Nugrahaningsih, M.Sc., Ph.D (4); Prof. Dr. Drs. Abdul Karim Zulkarnain, M.Si., Apt. (5)
Tanggal/Date 21 2021
Kata Kunci/Keyword
Abstrak/Abstract Background: Tithonia diversifolia has been widely developed as an anticancer therapy. Our previous study before showed that T.diversifolia was able to inhibit cell proliferation and collagen accumulation of keloid fibroblasts and decrease the index of rabbit scar hyperthrophy. The acute dermal toxicity study of T.diversifolia gel formulation did not show toxic effect for 14 days and the LD50 was estimated more than 2%. However, toxicity data subchronic dermal toxicity study were not available for this T. diversifolia gel formulation. Objective: Our study aimed to evaluate the subchronic dermal toxicity of T. diversifolia gel formulation in rats. Matherials and Methods :The T.diversifolia gel formulation with 3 dose variations of 2%, 10%, and 25% was administered topically. The lowest dose of 2% is the dose that has been used to decrease the index of rabbit scar hyperthrophy. We observed the toxic effect that may appear every day for 90 days period. Results: There were no significant toxic effects observed at all doses on physical sign and symptoms, body weight, food consumption, hematological parameters, biochemical parameters, and macroscopic and microscopics examination organs. Conclusion: The analysis NOAEL showed that the administration long term of the T.diversifolia gel formulation topically is safe to use within its dose recommendation.
Rumpun Ilmu Ilmu Kedokteran Dasar & Biomedis
Bahasa Asli/Original Language English
Level Internasional
Status
Dokumen Karya
No Judul Tipe Dokumen Aksi
1Accepted.pdfBukti Accepted
2TJPS-2021-0020_R2_Proof_hi.pdf[PAK] Full Dokumen
3font metter_TJPS hamsley.pdf[PAK] Halaman Cover
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