Sponge-Associated Fungi from Acorina sp. Showed Anti-cancer Activity Against Cancer Cell Line HeLa
Penulis/Author
Abrory Agus Cahya Pramana, S.Si., M.Sc. (1); EKA RAMADHANI (2); FAJAR PRIYAMBADA (3); Gian Aditya Pertiwi (4); RADEN ADITYA ARYANDI S (5); Dr.biol.hom. Nastiti Wijayanti, S.Si., M.Si. (6)
Tanggal/Date
1 2022
Kata Kunci/Keyword
Abstrak/Abstract
Nowadays, natural products from marine life especially sponge-associated fungi (SAF) have been getting extensive attention as candidates for anti-cancer agents. Although chemotherapy has been widely used as one of the cancer treatments, recently, multidrug resistance as one of its drawbacks has appeared. Our preliminary research successfully isolated 16 fungi isolates from Ancorina sp. habitating Kukup (KU) Beach, Yogyakarta, Indonesia. The ethyl acetate extracts of SAF KU4 fungi that were grown in enrichment broth media in sea water base either as media-free mycelium and whole medium were analyzed for the cytotoxicity level and the apoptotic effect on cervical cancer cell line (HeLa). SAF KU4 was cultured in Wickerham sea-based media, then, extracted using ethyl acetate. The IC50 values measured by MTT assay IC50 of the media-free extract and whole extract were 158.13 and 283.95 µg/mL respectively. Ethyl acetate extract of media-free mycelium and whole extract were moderately cytotoxic, but could induce apoptosis in HeLa cell lines.
Rumpun Ilmu
Biologi (dan Bioteknologi Umum)
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
officejmbfs,+jmbfs_3352_Pramana.pdf
[PAK] Full Dokumen
2
SPONGE-ASSOCIATED FUNGI ISOLATES FROM ANCORINA SP_ SHOWED ANTI-CANCER ACTIVITY AGAINST HELA CELL LINES.pdf
[PAK] Cek Similarity
3
2022_Bukti Korespondinsi_Pramana_Lengkap.pdf
[PAK] Bukti Korespondensi Penulis
4
2022_Pramana_SuKet_NastitiWijayanti_Rev1.pdf
Dokumen Pendukung Karya Ilmiah (Hibah, Publikasi, Penelitian, Pengabdian)
