Sun Protector Factor (SPF) In Vitro and the Physical Stability of o/w Cream Optimal Formula From the Partition Product of Mahkota dewa (Phaleria macrocarpa (Scheff) Boerl
Penulis/Author
Prof. Dr. Drs. Abdul Karim Zulkarnain, M.Si., Apt. (1); Prof. Dr. Marchaban, DESS. Apt. (2); Prof. Dr. apt. Subagus Wahyuono, M.Sc. (3); Prof. Dr. apt. Ratna Asmah Susidarti, MS. (4)
Tanggal/Date
2015
Kata Kunci/Keyword
Abstrak/Abstract
The leaves Mahkota dewa leaves (Phaleria macrocarpa (Scheff) Boerl) contain a benzophenoic glycoside (Phalerin) which are active for sun screen. Some formula and design on the Simplex Lattice Design (SLD) method and its physical characteristics were investigated. The physical characteristics will be used to determine the optimum formula. In present study, the optimum formulation was evaluated to determine chemical stability and the in vitro SPF (Sun Protecting Factor). The doses of partition product of P. macrocarpa used were used 6%. The optimal formulation cream was determined by SLD version 9.0.1 with variety of cetyl alcohol, mineral oil, and Tween 80. The difference of physical characteristics between experimental and software was analyzed using T-test, P= 95%. The physical stability and in vitro SPF of the optimum formula were observed. The study exhibits that the combination of cetyl alcohol 9.71%, mineral oil 29%, and tween 80 3.29% was the optimum formula of o/w cream with the desirability test 0.924. The T-test result shows that there is no significant differences (p>0.05) on physical characteristics between experimental and software prediction. During the storage, the viscosity, spread ability, adhesive ability, separation volume ratio of cream were relatively stable. However the stability started to decline on the week IV in the extreme temperature. The SPF of the cream of the CFR, CPHR and CBZP partition were 21.32; 33.12 and 42.49, respectively.
