Karya
Judul/Title Spectrum of Thyroid Stimulating Hormone (TSH) Level Determined by Radioimmunoassay (RIA) in Indonesian Neonates Population
Penulis/Author dr. Elizabeth Henny Herningtyas, M.Si., Ph.D. SpPK(K) (1) ; dr. Windarwati, Sp.PK(K)., M.Sc. (2); Dr. dr. Tri Ratnaningsih, Sp.PK(K).,M.Kes. (3)
Tanggal/Date 2011
Kata Kunci/Keyword
Abstrak/Abstract Congenital hypothyroid (CH) influences the baby growth, intelligence, and nerve degeneration/impairment. TSH is a well?known laboratory parameter for screening of congenital hypothyroid. At the population level, the CH screening is mainly performed by using monospot blood sample and TSH determination is relied on the available method. The threshold of TSH for screening of congenital hypothyroid may vary among different populations. There is not any information of spectrum of TSH level and threshold from Indonesian population yet. The aims of the study are to examine the range of TSH level determined by radioimmunoassay (RIA) and to identify the screening threshold of TSH level that gives an increasing risk for congenital hypothyroid in Indonesian neonate population. Using the data from population screening in year 2006?2007, we obtained 1028 eligible subjects, 541 male and 487 female that was screened for TSH using heel?prick dried blood spot from day 0 to 3 months after delivery. The distribution of TSH level based on gender and baby age showed that TSH level in both gender is high at the first day of delivery then gradually reduced to steady?state level by 7 days after birth. Average TSH level of male and female neonates were 6.41±4.08?IU/mL (threshold: 18.65 ?IU/mL) and 6.02±3.95 ?IU/mL (threshold: 17.87 ?IU/mL), respectively. Total average of TSH level in this population was 6.23±4.02 ?IU/mL (threshold: 19 ?IU/mL) that was 24% lower than the present standard threshold that might be involved in avoid missing of suspected cases.
Level Nasional
Status
Dokumen Karya
No Judul Tipe Dokumen Aksi
1Paper Henny.pdf[PAK] Full Dokumen
2hasil cek similarity - Spectrum of Thyroid Stimulating Hormone.pdfCek Similarity