SOME 2-ARYLBENZIMIDAZOLE DERIVATIVES AS AN ANTIMALARIAL AGENT: SYNTHESIS, ACTIVITY ASSAY, MOLECULAR DOCKING AND PHARMACOLOGICAL EVALUATION
Penulis/Author
Prof. Drs. Bambang Purwono, M.Sc., Ph.D. (1); BETA ACHROMI N (2); PANDJI ZAMZAMI FATHURROHMAN (3); JUFRIZAL SYAHRI (4)
Tanggal/Date
11 2021
Kata Kunci/Keyword
Abstrak/Abstract
A series of some 2-arylbenzimidazole derivatives have been synthesized from substituted aryl aldehyde and o-phenylenediamine using microwave radiation and tested for its antimalarial activity. The 2-(4-methoxyphenyl)-1H-benzimidazole showed excellent in vitro antimalarial activity toward Plasmodium falciparum (3D7) strain. Molecular docking studies have supported in vitro antimalarial assay. This compound also showed good bioavailability and druglike properties.
