Karya
Judul/Title Solubility Enhancement of Simvastatin through Surfactant Addition for Development of Hydrophobic Drug-Loaded Gelatin Hydrogel ,
Penulis/Author Dr. drg. Niswati Fathmah Rosyida, MDSc (1); Prof. Dr. drg. Pinandi Sri Pudyani, SU.,Sp.Ort(K). (2); Prof. Dr. apt. Akhmad Kharis Nugroho, S.Si., M.Si. (3); Prof. drg. Ika Dewi Ana, M.Kes., Ph.D. (4); Dr.-Ing. Ir. Teguh Ariyanto, ST, MEng., IPM. (5)
Tanggal/Date 2019
Kata Kunci/Keyword
Abstrak/Abstract This study aims to synthesize simvastatin hydrogel as drug delivery system with surfactant addition for improving solubility of simvastatin. Surfactants used in the study were the zwitterionic amino acid of arginine and nonionic surface-active agent of polysorbate 80. The solubility study was conducted by pouring of an excess mass of simvastatin into the solution of a surfactant in a conical flask. The sample was shaken up to 72 h in a mechanical water bath shaker at a varied temperature of 25, 40, and 50 °C. The amount of drug dissolved in solution was analyzed by UV/Visible spectrophotometer at 238 nm. The results showed that the simvastatin solubility is profoundly influenced by the surfactant type, surfactant concentration, and temperature. Polysorbate 80 exhibited as a better surfactant than arginine and an enhancement up to 1400 times, in respect of without any addition of a surfactant, was observed. Based on the solubility study, simvastatin-loaded gelatin hydrogel composite was formulated and the characterization (FTIR and SEM) showed the successful impregnation. The hydrogel microparticles presented a sustained release profile.
Rumpun Ilmu Ortodonsia
Bahasa Asli/Original Language English
Level Internasional
Status
Dokumen Karya
No Judul Tipe Dokumen Aksi
1IJC_full document.pdf[PAK] Full Dokumen
2Abstrak Disertasi Niswati.pdf
3Akreditasi Indonesian Journal of Chemistry.pdf
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5Solubility enhancement of simvastatin through surfactant addition for development of hydrophobic drug-loaded gelatin hydrogel.pdf[PAK] Full Dokumen