| Abstrak/Abstract |
Abstract: Pursuing further orthodontic treatment for functional and cosmetic purposes is increasingly captivating. Clinicians must thoroughly understand tissue reactions during orthodontic relapse to prevent post-orthodontic relapse, such as managing inflammation and bone remodeling. Biological therapies, including biomaterials, can promote bone growth and prevent bone resorption, which can significantly accomplish bone remodeling and reduce relapse. As an anti-inflammatory substance, silk sericin from natural composite Bombyx mori can potentially reduce pro-inflammatory cytokines in the bone remodeling process and directly reduce osteoclast formation and activation. Chitosan acts as an osteoclast inhibitor and enhances bone regeneration by increasing osteoblast maturation. This condition can reduce the risk of orthodontic relapse. Both of these biomaterials have the ability to regulate the synthesis of inflammatory mediators, including decreasing pro-inflammatory cytokines, increasing bone regeneration, regulating the immune response, and preventing the production of oxidative stress species. These findings can serve as crucial strategies for preventing orthodontic relapse by regulating alveolar bone remodeling. Despite all the benefits of sericin and chitosan, further studies are needed to focus on understanding their formulation and in vitro and in vivo testing to ensure effectiveness on a global scale. |
