Sex differences in the association of vitamin D and metabolic risk factors with carotid intima-media thickness in obese adolescents
Penulis/Author
Prof. dr. Indah Kartika Murni, M.Kes., Sp.A(K)., Ph.D. (1); Dian Caturini Sulistyoningrum, B.Sc., M.Sc. (2); Danijela Gasevic (3); dr. Rina Susilowati, Ph.D. (4); Prof. dr. Madarina Julia, Sp.A(K), MPH., Ph.D. (5)
Tanggal/Date
15 2021
Kata Kunci/Keyword
Abstrak/Abstract
Background
It has been shown that vitamin D is associated with obesity and the development of atherosclerosis.
Less is known about this association among adolescents with obesity.
Objectives
To determine the association of vitamin D level and metabolic risk factors with carotid
intima-media thickness (CIMT) among obese adolescents.
Methods
We conducted a cross-sectional study among obese children aged 15 to 17 years in Yogyakarta,
Indonesia. The association of vitamin D and other metabolic risk factors (triglyceride,
low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDLC),
and insulin resistance using homeostasis model assessment of insulin resistance
(HOMA-IR)) with CIMT was explored by multivariable linear regression models.
Results
Out of 156 obese adolescents, 55.8% were boys. Compared to girls, boys had higher BMI zscore,
waist circumference, and HDL-cholesterol. After adjustment for age, sex and second-
hand smoke exposure, high HOMA-IR, total cholesterol, LDL-cholesterol and triglyceride
levels were associated with higher odds of elevated CIMT. In analyses stratified by sex,
a similar trend was observed in boys, while none of the risk factors were associated with
CIMT in girls. We observed no association between vitamin D and CIMT.
Rumpun Ilmu
Ilmu Kedokteran Umum
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
5_ Sex differences in the association of vitamin D and metabolic risk factors with carotid intima-media thickness in obese adolescents.pdf
