| Abstrak/Abstract |
The purpose of this study was to formulate a self-nanoemulsifying drug delivery system (SNEDDS) from black
soldier fly oil (BSFO) as a possible antibiotic substitute in chicken. Using Design Expert Ver.13.0.1.0, an I-optimal
combination was created by altering the concentrations of the oil components BSFO, polyethylene glycol 400
(PEG 400) (v/v), and Tween 80. This mixture was then used to analyze the optimal formula. The parameters for
optimization were chosen to be the emulsification time and transmittance percentage. Droplet size, polydispersity
index (PDI), zeta potential (ZP), viscosity, thermodynamic stability, and morphology were used to characterize the
ideal formula. The formulation of the SNEDDS from BSFO using 11.426% of BSFO, 73.364% of Tween 80, and
11.177% of PEG 400 was successful. Results displayed a high transmittance percentage, a brief emulsification time,
a small droplet size, with a PDI of 0.36% ± 0.0%, ZP −19.4 mV, the SNEDDS viscosity was at 387.33 ± 22.81 mPa·s,
and the nanoemulsion viscosity was at 10.47 ± 0.42 mPa·s, fit the assay for thermodynamic stress, and showed signs
of having a sphere-like form. This study suggested that the formulation improved the solubility, absorption, and
antibacterial agent a possible antibiotic substitute in the production of chicken. |
