Screening test for COVID-19 in outpatient settings: a rapid review
Penulis/Author
dr. Antonia Morita Iswari Saktiawati., Ph.D (1); TAUFIK MULYA PERDANA (2); dr. Vicka Oktaria, M.P.H., Ph.D (3); Prof. dr. Indah Kartika Murni, M.Kes., Sp.A(K)., Ph.D. (4); dr. Elizabeth Henny Herningtyas, M.Si., Ph.D. SpPK(K) (5)
Tanggal/Date
20 2021
Kata Kunci/Keyword
Abstrak/Abstract
Background
The screening for SARS-CoV-2 during this pandemic is crucial to limit the virus's spread by identifying and contact tracing of individuals with or without symptoms suggesting COVID-19 to reduce further disease transmission. The evidence-based best-performed screening test for COVID-19 needs to be identified.
Methods
To estimate the screening test accuracy against RT-PCR for COVID-19, we screened multiple databases until December 2, 2020.
Findings
We included seven studies with 1536 subjects in the analysis. Serological assay studies' pooled sensitivity and specificity were 10% (95% CI: 7-13) and 92% (95% CI: 89-96), respectively, and no heterogeneity was found. The pooled PPV of serological assays studies was 70% (95% CI:60-80) and pooled NPV was 56% (95% CI:52-60). The pooled diagnostic accuracy of other tests (clinical symptoms, antigen test, chest CT-scan) cannot be determined as only a few studies available. The sensitivity and specificity of other tests ranged from 0% to 100% and 21.3% to 100%, respectively. The strength of evidence within all seven studies was low to moderate.
Interpretation
The medium evidence of these studies shows that serology assay is not accurate for COVID-19 screening. Once other screening tests have real-life implementation data, the pooled diagnostic accuracy can be determined.
