ACADSTAFF UGM

Karya

Judul/Title	Safe-by-Design Antibacterial Peroxide Substituted Biomimetic Apatites: Proof of Concept in Tropical Dentistry
Penulis/Author	Prof. drg. Ika Dewi Ana, M.Kes., Ph.D. ⁽¹⁾; Any Lestari ⁽²⁾; Prescillia Lagarrigue ⁽³⁾; Jérémy Soulie ⁽⁴⁾; Rahmi Anggraeni ⁽⁵⁾; Françoise Maube-Bosc ⁽⁶⁾; Carole Thouron ⁽⁷⁾; Benjamin Duployer ⁽⁸⁾; Christophe Tenailleau ⁽⁹⁾; Christophe Drouet ⁽¹⁰⁾
Tanggal/Date	7 2022
Kata Kunci/Keyword
Abstrak/Abstract	Bone infections are a key health challenge with dramatic consequences for affected patients. In dentistry, periodontitis is a medically compromised condition for efficient dental care and bone grafting, the success of which depends on whether the surgical site is infected or not. Present treatments involve antibiotics associated with massive bacterial resistance effects, urging for the development of alternative antibacterial strategies. In this work, we established a safe-by-design bone substitute approach by combining bone-like apatite to peroxide ions close to natural in vivo oxygenated species aimed at fighting pathogens. In parallel, bone-like apatites doped with Ag+ or co-doped Ag+/peroxide were also prepared for comparative purposes. The compounds were thoroughly characterized by chemical titrations, FTIR, XRD, SEM, and EDX analyses. All doped apatites demonstrated significant antibacterial properties toward four major pathogenic bacteria involved in periodontitis and bone infection, namely Porphyromonas gingivalis (P. gingivalis), Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Fusobacterium nucleatum (F. nucleatum), and S. aureus. By way of complementary tests to assess protein adsorption, osteoblast cell adhesion, viability and IC50 values, the samples were also shown to be highly biocompatible. In particular, peroxidated apatite was the safest material tested, with the lowest IC50 value toward osteoblast cells. We then demonstrated the possibility to associate such doped apatites with two biocompatible polymers, namely gelatin and poly(lactic-co-glycolic) acid PLGA, to prepare, respectively, composite 2D membranes and 3D scaffolds. The spatial distribution of the apatite particles and polymers was scrutinized by SEM and µCT analyses, and their relevance to the field of bone regeneration was underlined. Such bio-inspired antibacterial apatite compounds, whether pure or associated with (bio)polymers are thus promising candidates in dentistry and orthopedics while providing an alternative to antibiotherapy.
Bahasa Asli/Original Language	English
Level	Internasional
Status	Published

Dokumen Karya

No	Judul	Tipe Dokumen
1	Safe-by-Design Antibacterial Peroxide-Substituted Biomimetic Apatites Proof of Concept in Tropical Dentistry_compressed.pdf	[PAK] Full Dokumen
2	jfb-13-00144-v3 (2)_compressed.pdf	Bukti Published
3	form-L1-permohonan_penghargaan-karya-ilmiah-sudah-terbit-pada-jurnal-Q1Q2-IF_2022 - ID Ana.pdf	Dokumen Pendukung Karya Ilmiah (Hibah, Publikasi, Penelitian, Pengabdian)
4	form-L2-persetujuan_penghargaan-karya-ilmiah-sudah-terbit-pada-jurnal-Q1Q2-IF_2022 - ID Ana - FKG UGM.pdf	Dokumen Pendukung Karya Ilmiah (Hibah, Publikasi, Penelitian, Pengabdian)
5	form-L3-surat pernyataan_penghargaan-karya-ilmiah-sudah-terbit-pada-jurnal-Q1Q2-IF_2022 - ID Ana - FKG UGM.pdf	Dokumen Pendukung Karya Ilmiah (Hibah, Publikasi, Penelitian, Pengabdian)
6	Print Out Google Scholar - Safe-by-Design - JFB 2022.pdf	Dokumen Pendukung Karya Ilmiah (Hibah, Publikasi, Penelitian, Pengabdian)
7	Hibah IF Tinggi - ID Ana - Lengkap - Naskah L1 L2 L3 Print Out Google Scholar _compressed.pdf	Dokumen Pendukung Karya Ilmiah (Hibah, Publikasi, Penelitian, Pengabdian)
8	form-L1-permohonan_penghargaan-karya-ilmiah-sudah-terbit-pada-jurnal-Q1Q2-IF_2022 - ID Ana.pdf	Dokumen Pendukung Karya Ilmiah (Hibah, Publikasi, Penelitian, Pengabdian)
9	form-L2-persetujuan_penghargaan-karya-ilmiah-sudah-terbit-pada-jurnal-Q1Q2-IF_2022 - ID Ana - FKG UGM.pdf	Dokumen Pendukung Karya Ilmiah (Hibah, Publikasi, Penelitian, Pengabdian)
10	form-L3-surat pernyataan_penghargaan-karya-ilmiah-sudah-terbit-pada-jurnal-Q1Q2-IF_2022 - ID Ana - FKG UGM.pdf	Dokumen Pendukung Karya Ilmiah (Hibah, Publikasi, Penelitian, Pengabdian)
11	Print Out Google Scholar - Safe-by-Design - JFB 2022.pdf	Dokumen Pendukung Karya Ilmiah (Hibah, Publikasi, Penelitian, Pengabdian)
12	Hibah IF Tinggi - ID Ana - Lengkap - Naskah L1 L2 L3 Print Out Google Scholar _compressed.pdf	Dokumen Pendukung Karya Ilmiah (Hibah, Publikasi, Penelitian, Pengabdian)