Karya
Judul/Title Roles of HtrA1 in non-hypertensive arteriosclerosis
Penulis/Author Dr. apt. Muthi' Ikawati, M.Sc. (1); Antono Pangestu Hadi (2); Masashi Kawaichi (3); Chio Oka (4)
Tanggal/Date 2013
Kata Kunci/Keyword
Abstrak/Abstract Loss-of-function mutations of human HtrA1 cause a non-hypertensive ischemic cerebral small-vessel disease called CARASIL, which is characterized by severe arteriosclerosis. We have generated HtrA1 knock- out (KO) mice to understand the roles of HtrA1 in maintenance of normal arteries. The KO mice develop normally to adulthood. The brain arteries of KO mice are normal even 52 weeks after birth. Interestingly the aorta is larger and smooth muscle cells (SMC) are decreased in KO mice at 38-42 and 52 weeks of age than wild type (WT) littermates. Moreover, 52-weeks old KO mice show increase in local intimal proliferation. We hypothesize that HtrA1 is involved in vascular SMC differentiation.
Rumpun Ilmu Biologi (dan Bioteknologi Umum)
Level Internasional
Status
Dokumen Karya
No Judul Tipe Dokumen Aksi
120131013-ICCAD 2013.pdf[PAK] Sertifikat Seminar
22013-ICCAD-Editorial.pdf[PAK] Informasi Dewan Redaksi/Editor/Steering Committee
32013-ICCAD-cover.pdfSeminar Sampul Prosiding
42013-ICCAD-full article.pdf[PAK] Full Dokumen
52013-ICCAD-table of content.pdfDaftar Isi
6h_ ICCAD 2013 Abstract-Cardiology supplement-Scopus.pdf
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