The efficacy of the drug encapsulated in the polymeric matrix is closely related to the kinetics of drug release from the matrix, therefore the study about the kinetic release of a drug from a certain matrix is essential to be carried out. This study aims to evaluate the release of β-carotene from the starch-chitosan crosslinked by tripolyphosphate matrices (starch-chitosan/TPP) in the in vitro digestive media (artificial intestinal fluid (AIF) and artificial gastric fluid (AGF)) as well as in ethanol, and to evaluate the antioxidant activity of the released β-carotene. The effect of starch types, i.e. native and acid hydrolyzed starch, on both parameters was investigated. The results show that the β-carotene release in AIF is slower than that in AGF. In each applied medium, the release rate of β-carotene from hydrolyzed starchchitosan/TPP matrices is slower than from native starch-chitosan/TPP matrices. The release kinetics of β-carotene in absolute ethanol medium follows the Korsmeyer-Peppas model with an exponent of release (n) value for encapsulation products using the native starch-chitosan/TPP matrix and using the hydrolyzed starch-chitosan/TPP matrix are 0.14 and 0.16, respectively. This value indicates that the mechanism of β-carotene release in both matrices follows the
quasi-fickian diffusion. Furthermore, the antioxidant activity of β-carotene released from the matrices does not decrease significantly after encapsulation, indicating the effectiveness of the matrices in protecting the activity β-carotene.
Rumpun Ilmu
Kimia
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
A Dyah Novita Lestari_RJC_2021.pdf
[PAK] Full Dokumen
2
RELEASE KINETICS AND ANTIOXIDANT ACTIVITY OF ?-CAROTENE ENCAPSULATED IN STARCH-CHITOSAN_TRIPOLYPHOSPHATE MATRICES.pdf
