Quantitative Structure Activity Relationship (QSAR) study and Biological evaluation on Mono-ketone analogs of Curcumin as Antioxidant
Penulis/Author
BAMBANG WIJIANTO (1); Prof. Dr. Ritmaleni,S.Si. (2); Dr. Drs. Hari Purnomo, M.S., Apt. (3); Prof. Dr. apt. Arief Nurrochmad, M.Si., M.Sc. (4)
Tanggal/Date
2020
Kata Kunci/Keyword
Abstrak/Abstract
The objective of this study was to design new mono-ketone analogs of curcumin and determine its lipid
peroxidation inhibition. Molecular modeling studies were carried out by using the semi-empirical quantum
chemical algorithm AM-1 method in MOE 2018.01.01 software. Build QSAR was used to generate an equation
model that will be used to design new mono-ketone analogs of curcumin. Synthesis of new compounds produced
from an aldol condensation reaction. Thiobarbituric acid reactive substance (TBARS) method was used to
determine antioxidant activity by measuring lipid peroxide concentration. Promising predictions values of lipid
peroxidation the QSAR study obtained inhibitory activity. The in vitro lipid peroxidation inhibition of 2,6-bis-
(3'-ethoxy, 4'-hydroxybenzylidene)-cyclohexanone; 2,6-bis-(3'-Bromo,4'-methoxybenzylidene)-cyclohexanone;
and 2,6-bis-(3',4'-dimethoxybenzylidene)-cyclohexanone indicates good inhibitory with IC50 values of 2.95;
0.95; and 2.45?M respectively. The new mono-ketone analogs of curcumin compound from the QSAR study has
been shown to have antioxidant activity by inhibiting lipid peroxidation by scavenging free radicals.
Rumpun Ilmu
Analisis Farmasi dan Kimia Medisinal
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
Research J Pharm and Tech 13(10) October 2020.pdf
[PAK] Full Dokumen
2
Quantitative Structure Activity Relationship (QSAR) study and Biological evaluation on Mono ketone analogs of Curcumin as Antioxidant.pdf
[PAK] Cek Similarity
3
RJPT Bambang Oktober 2020 - Bukti korespondensi artikel.pdf
