| Penulis/Author |
INTAN MARTHA CAHYANI (1); Dr. Adhyatmika, M.Biotech., Apt. (2); Prof. Dr.rer.nat. apt. Raden Rara Endang Lukitaningsih, S.Si., M.Si. (3); Prof. Dr. Teuku Nanda Saifullah Sulaiman, S.Si., M.Si., Apt. (4) |
| Abstrak/Abstract |
Microcrystalline Cellulose (MCC) serves a diverse range of functions in various food, cosmetic, and pharmaceutical. It plays a crucial role
as an excipient in the pharmaceutical industry, especially in tablet manufacturing, including as a filler, binder, and disintegrant. Sengon Wood Sawdust (SWS) contains 50.85?llulose so it has the potential to be a promising source of MCC both in terms of its function in the pharmaceutical industry and in efforts to increase the benefits and economic value of wood industry waste. MCC extraction was carried out in three stages, namely alkaline delignification to obtain α-cellulose, continued with acid hydrolysis, and bleaching to obtain MCC. This process has been known to increase cellulose content up to 85.01%. This study aims to determine the pharmacopoeial properties of
Microcrystalline Cellulose from Sengon Wood Sawdust (SWS-MCC). Several pharmacopoeial properties were assessed, including compressibility tests, considering its intended use as a drug delivery biomaterial. The research results show that SWS-
MCC is similar to Avicel® PH 102 as a commercial comparison and meets all pharmacopoeial parameters, that have been carried out including microbial excipient quality. Several results also reveal that SWS-MCC is better than Avicel® PH 102, including moisture content (4.38%), flow rate (88.384 g/s), angle of repose (36.17), Carr's index (12.67%), and Hausner ratio (1.15). It was concluded that SWS, despite being waste, holds promise as a cost-effective, functional, and sustainable as a pharmaceutical excipient, especially for direct compression tableting. |
