| Abstrak/Abstract |
Introduction: Metformin is given together with herbs in order to optimize its mechanism of action. The effect might be positive and vice versa. Interaction might occur pharmacokinetics or pharmacodynamically. The study aimed to review the potential interaction of metformin and some herbs with various pharmacological activities. Methods: This literature review was conducted by collecting articles with keywords Metformin, Herb-drug Interaction, drug interaction, pharmacokinetics, pharmacodynamics, and pharmacology from international databases such as Science Direct, PubMed, Springer Link, and Scopus up to 2021. Results: Metformin with its various uses such as an antidiabetic agent, an agent for reducing weight for patients that are sensitive or even resistant to insulin, patients with obesity, an anti-tumor agent, an anti-cancer potential agent, and also has anti-aging potential. Metformin could interacted with drugs, herbs, and also some bioactive isolates. The interaction might occurs pharmacokinetically or pharmacodynamically. Pharmacokinetics interactions occurred during distribution and also excretion via transporters that metformin was transported with. This was shown as the elevated or lowered metformin levels in the blood. Pharmacodynamic interactions can be seen as the lowering or elevated levels of glucose, HbA1c, and even the lipid profile in blood or plasma. Conclusion: According to this literature review, Metformin has a potential interaction with drugs, herbs,
and also some bioactive isolates. The interactions occur pharmacokinetically or pharmacodynamically. This
study can be used as an established familiarity with and understanding of the potential HDIs from Metformin
and herbal products |
