Potential of Syzygium aromaticum (Clove) Leaf Extract on Immune Proliferation Response in Balb/c Mice Infected with Salmonella typhimurium
Penulis/Author
SYAHRAN WAEL (1); Theopilus Wilhelmus Watuguly (2); Ine Arini (3); Alwi Smit (4); Nur Matdoan (5); Dwi Retna Prihati (6); Ana Bina Sari (7); Didik Wahyudi (8); Dr. Tri Rini Nuringtyas, S.Si., M.Sc. (9); Dr.biol.hom. Nastiti Wijayanti, S.Si., M.Si. (10); Dr. drh. Pudji Astuti M.P. (11)
Tanggal/Date
24 2018
Kata Kunci/Keyword
Abstrak/Abstract
Background and Objective: Syzygium aromaticum is an immunomodulator
with the main active compound eugenol which can stimulate the function of
lymphocyte proliferation and macrophage production. Lymphocytes play an
important role for body protection against infection. This study aims to analyze
the effect of S. aromaticum extract to increase proliferation of lymphocytes,
lymphoblasts and macrophage production in Balb/c mice infected with
Salmonella typhimurium. Methodology: Mice strain Balb/c were divided into 4
groups: treatment group infected with S. typhimurium and control group
(without treatment) to tested the activity of peritoneal macrophages. The
treatment group was administrated by S. aromaticum leaf extract (15 mg, 75 mg,
150 mg/kgbw) for 12 days. Results: S. aromaticum leaf extract increased the
proliferation activity (p < 0.001) at dose of 15, 75, and 150 mg/kgbw, increased
lymphocytes at dose 150 mg/kgbw (p < 0.05), increased the activity of macrophage
ROI secretion at dose of 150 mg/kgbw (p < 0.05), and increased in lymphoblast
(p < 0.05). Conclusion: Administration of S. aromaticum leaf extract
increased the proliferation activity of lymphocytes, lymphoblasts and ROI
secretion of macrophagesin Balb/c mice infected with S. typhimurium.
