Potential Lactogenic Effects in Extract Combinations of Carica papaya.L and Sauropus androgynus Leaves
Penulis/Author
DEWI KURNIATI (1); Dr. dr. Rul Afiyah Syarif, M.Kes. (2); Prof. Dr. Mae Sri Hartati Wahyuningsih, Apt., M.Si. (3); Dr. dr.. Ekawaty Lutfia Haksari, MPH., Sp.A(K). (4)
Tanggal/Date
1 2025
Kata Kunci/Keyword
Abstrak/Abstract
The leaves of Carica papaya and Sauropus androgynus are known to increase breast milk production (lactogenic). This study aimed to determine the lactogenic effect of the combination of leaf extracts from C. papaya and S. androgynus on breast milk production, oxytocin, and prolactin hormone levels. The Wistar rats were divided into 6 groups, each consisting of 4 rats. The groups were as follows: negative control; C. papaya leaf extract (ECP) 72 mg/kg BW; S. androgynus leaf extract (ESA) 81 mg/kg BW; combination of ECP 72 mg/kg BW + ESA 81 mg/kgBW; combination of ECP 72 mg/kg BW + ESA 162 mg/kg BW; combination of ECP 144 mg/kg BW + ESA 81 mg/kg BW. Treatments commenced from day 3 to day 15 of lactation. Milk production was determined by daily weighing of pup weight changes. Blood oxytocin and prolactin hormone levels were measured using enzyme-linked immunosorbent assay (ELISA) and analyzed using one-way ANOVA. Breast milk production significantly increased in the group receiving the combination of ECP 144 mg/kg BW + ESA 81 mg/kg BW compared to the other treatment groups. After treatment, blood oxytocin and prolactin hormone levels significantly increased in the groups receiving the combination of ECP 144 mg/kg BW + ESA 81 mg/kg BW and ECP 72 mg/kg BW+ESA 81 mg/kg BW compared to the before treatment (p < 0.05). The combination of C. papaya and S. androgynus leaf extracts enhances breast milk production, oxytocin and prolactin hormones.
Rumpun Ilmu
Ilmu Kedokteran Dasar & Biomedis
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
2025 Rul dkk TJNPR Potential lactogenic effects extrac combination C papaya and S androgynus.pdf
