Polymer as precipitation inhibitor of weak base drug: An update and brief review
Penulis/Author
VIVIANE ANNISA (1); SYAIFUL CHOIRI (2); Prof. Dr. Teuku Nanda Saifullah Sulaiman, S.Si., M.Si., Apt. (3); Prof. Dr. apt. Agung Endro Nugroho, S.Si., M.Si. (4)
Tanggal/Date
16 2021
Kata Kunci/Keyword
Abstrak/Abstract
Precipitation due to supersaturation phenomenon and intraluminal solubilization behavior is mainly faced on reducing bioavailability, particularly for weak base drugs. Incomplete and extend of absorption can be avoided by modification of drug-excipient interaction namely polymers. This interaction is proposed to stabilize the amorphous form of drug through reducing nucleation followed by crystal growth. Therefore, polymers can be utilized to inhibit the precipitation phenomenon through their interaction with poorly water-soluble and weak base drugs. However, until to date, there was no recent updates on the use of polymer for precipitation inhibitor of weak base drug. This review discussed the brief and recent updates on polymer as precipitation inhibitor of weak base drug during intraluminal solubilization behavior namely mechanism, factors, and polymer application.
Rumpun Ilmu
Farmasetika dan Teknologi Farmasi
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
Bukti Korespondensi_Polymer as precipitation inhibitor of weak base drug An update and brief.pdf
[PAK] Bukti Korespondensi Penulis
2
full---tjps-vol-45-no-5-2021-pp-326-332pdf.pdf
[PAK] Full Dokumen
3
Polymer as precipitation inhibitor of weak base drug_ An update and brief review.pdf
