| Abstrak/Abstract |
The gold standard procedure for gingival recession is the free gingival graft (FGG), although it
leaves an open wound in the donor area that is prone to problems. Platelet-rich Fibrin (PRF) has
been shown to aid in the healing of palatal wounds. Nonetheless, there hasn't been much debate
about the PRF's mechanism. The purpose of this narrative review was to discuss about the effects
and mechanisms of PRF components on palatal wound healing following FGG.
In vivo and in vitro experiments revealed that PRF reduces delayed bleeding because of its
mechanical qualities, which act as mechanical protection and restore destroyed tissue components.
PRF's high platelet content stimulates platelet aggregation when it comes into contact with injured
blood vessel collagen, which helps to maintain hemostasis. Platelet activation also promotes cell
migration and proliferation within the fibrin matrix. Platelets also regulate the release of growth
factors such as PDGF, IGF-1, EGF, VEGF, and TGF-β, which activate macrophages, fibroblasts,
and endothelial cells in blood vessels. The presence of leukocytes impacts healing by commencing
the neoangiogenesis process. By analyzing the patient's pain level, clinical trials discovered lower
inflammation in palatal wounds treated with PRF. Furthermore, PRF has been demonstrated to
considerably accelerate palatal wound epithelialization.
PRF is preferable when used as a wound dressing for the palate following FGG. Platelets,
leukocytes, growth factors, fibrin matrix, and anti-inflammatory cytokines can all see increased
expression as a result of this factor's involvement. |
