Plant natural products for cognitive impairment: A review of the preclinical evidence
Penulis/Author
HELMI (1); Prof. Dr.rer.nat. Nanang Fakhrudin, M.Si., Apt. (2); Prof. Dr. apt. Arief Nurrochmad, M.Si., M.Sc. (3); Prof. Dr. apt. Zullies Ikawati. (4)
Tanggal/Date
5 2021
Kata Kunci/Keyword
Abstrak/Abstract
Cognitive impairment (CI) is a highly complex central nervous system disorder commonly associated with aging. This
condition is characterized by a progressive reduction of cognitive function. Modern synthetic drugs have been granted
clinical approval for the treatment of CI. However, most of these drugs show insufficient efficacy and undesired side
effects in clinical practice. Alternative drugs for CI are required to overcome these problems. Medicinal plants and their
bioactive molecules remain the main sources for new drug discovery, and they have the potential to be developed as
novel drugs for CI. Many reports have demonstrated the activity of other medicinal plants and their active metabolites
for CI in various experiments. In this article, we summarize the potency of plant natural compounds for CI, focusing
on cognitive-enhancing activity in amnesic-animal experimental models. We also discuss the pathophysiological
basis of CI and propose potential therapeutic targets of CI using plant natural compounds. Additionally, we highlight
promising natural compounds for CI and discuss their possible mechanisms of action. This review provides insight
into the effort of discovery and development of pharmaceutical agents derived from medicinal plants to combat CI.
Rumpun Ilmu
Biologi Farmasi
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
3375_pdf_Plant natural products for cognitive impairment A review of the preclinical evidence.pdf
