| Penulis/Author |
ERZA GENATRIKA (1) ; Prof. Dr. Ika Puspita Sari, S.Si., M.Si., Apt. (2); Prof. Dr. Susi Ari Kristina, S.Farm., M.Kes., Apt. (3); Prof. Dr. Teuku Nanda Saifullah Sulaiman, S.Si., M.Si., Apt. (4) |
| Abstrak/Abstract |
Background: Inpatients requiring parenteral nutrition (PN) often need to receive intravenous
medication, but physical instability can occur between medications and PN. This review aimed to bring
together the available literature on the physical stability of medication with PN used in hospitals.
Methods: We conducted a systematic electronic literature search of PubMed, Science Direct, and
SpringerLink during the period 2009-2019 for all English language research publications evaluating the
physical stability of commonly used medication administered by PN in hospital. Results: Out of 88
studies, 7 studies selected for this review. From all studies conducted in this review found 14
combinations of drugs that are not compatible with PN admixtures, including levetiracetam, albumin,
amoxicillin, cefepime, esomeprazole, fluorouracil, pantoprazole, tropics, trace elements, vitamins, and
vancomycin. For adding medications directly to the PN solution, specific criteria should be considered,
such as physicochemical properties of the ingredients and drug concentration. Conclusion: The stability
of IV medications and PN is an important concern in delivering safe and effective medication and
nutritional therapy. The role of healthcare professionals is needed to avoid this incident so that patient
safety can be guaranteed. |
