Optimization of Formula Granule of Lempuyang Gajah (Zingiber zerumbet (L) J.E.Smith) Rhizome Purified Extract as a Larvicide
Penulis/Author
Dr. Tri Murini, Apt., M.Si. (1); Prof. Dr. Mae Sri Hartati Wahyuningsih, Apt., M.Si. (2); Prof. Dr. apt. Achmad Fudholi, DEA. (3); Prof. dr. Tri Baskoro Tunggul Satoto, M.Sc., Ph.D. (4)
Tanggal/Date
2 2020
Kata Kunci/Keyword
Abstrak/Abstract
Lempuyang gajah rhizome (Zingiber zerumbet (L) Smith is considered potential as larvicidal. A
previous study has shown that the purified extract of Z. zerumbet rhizome was toxic against Adese aegypti
larvae. The aim of the study it to formulate a purified extract of Z. zerumbet (L) Smith in granule
preparations by combining Sodium starch glycolate, PVP K-30 and tween 80. The granule formulation was
optimized by the Simplex Lattice Design (SLD) method with using Design expert program 7.1.5. The results
showed that the interaction of the three components can increase the flow rate index, the angle of repose,
and reduce absorption. The optimum formula obtained was Sodium starch glycolate 2%, PVP K-30 2%, and
Tween 80 5%. The analysis of one sample t-test shows that there is no significant difference between the
predicted parameter values and the experimental results of the flow rate index and angle of repose, while
the absorption response is significantly different. The optimum formula for granules has larvicidal activity
with 100% larval death during 12-hour treatment.
