| Abstrak/Abstract |
Based on recent studies, the ethanolic extract of Kembang Bulan leaves (Tithonia
diversifolia[A.Gray]) has an anti-keloid effect. This study aims to determine the
optimum formula for cream preparations with paraffinum liquidum, cetyl
alcohol, and stearyl alcohol. Inappropriate comparison of additional ingredients
results in the physical properties of the preparation becoming unstable during
storage. The optimum formula was obtained from the optimization using Simplex
Lattice Design (SLD) by software Design Expert version 10.0. The parameters
measured were viscosity, pH, spreadability, adhesive ability, and accelerated
study (centrifugation). The optimum cream formula consists of 19.11% b / b;
Cetyl alcohol with a level of 2.01% b / b; stearyl alcohol with a level of 1.49% b
/ b with a viscosity of 134.35 dPa.s, a spread of 5.78 cm, pH 6.243, and adhesive
ability of 13.61 seconds. The cream base produced is milky white, has a viscosity
of 143.99 dPa.s, a spread of 5.7 cm, pH 6.305, and adhesion to 14.57 seconds.
There is a significant difference in viscosity and pH of the experimental and
software prediction. However, there is no significant difference in adhesive
ability and spreadability response. The cream base and ethanolic extract of
Kembang Bulan leaves have a significant difference in physical stability except
for its spreadability. During the 4 weeks of storage, both of the creams are
relatively stable. The cream is stable after centrifugation |
