ONE-POT SYNTHESIS, ANTIOXIDANT ACTIVITY AND TOXICITY EVALUATION OF SOME HYDROXYXANTHONES
Penulis/Author
Emmy Yuanita (1); Harno Dwi Pranowo (2); Prof. Drs. Dwi Siswanta, M.Eng., Ph.D. (3); Respati Tri Swasono, S.Si., M.Phil., Ph.D (4); Prof. Dr. Mustofa, Apt., M.Kes. (5); Prof. Dr. Drs. Abdul Karim Zulkarnain, M.Si., Apt. (6); Prof. Dr. Jumina (7)
Tanggal/Date
2012
Kata Kunci/Keyword
Abstrak/Abstract
Some new hydroxyxanthone compounds were prepared through one pot cyclodehydration reaction of hydroxybenzoic acid derivatives (salicylic acid or resorcylic acid) with phloroglucinol or pyrogallol in the presence of Eaton’s reagent (P2O5/MeSO3H). The synthesized compounds were screened for their antioxidant activities by 2,2-diphenyl-1-picrylhydrazyl (DPPH) methods to determine their inhibitory concentration (IC50). Cytotoxicity of the prepared compounds was also evaluated by MMT assay on Vero cell line. It was observed that the position and the number of hydroxyl groups could significantly affect the potent antioxidant activity of the prepared compounds. Cytotoxicity evaluation of new compounds indicated that the synthesized series of hydroxyl xanthone were categorized as very strong antioxidants and showed potential development as a commercial antioxidant compound.
Rumpun Ilmu
Farmasetika dan Teknologi Farmasi
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
ONE-POT SYNTHESIS, ANTIOXIDANT ACTIVITY AND TOXICITY EVALUATION OF SOME HYDROXYXANTHONES.pdf
