Karya
Judul/Title Novel Self-Nano Emulsifying Drug Delivery System (SNEDDS) of andrographolide isolated from Andrographis paniculata Nees: Characterization, in-vitro and in-vivo assessment
Penulis/Author YANDI SYUKRI (1) ; Dr.rer.nat. Ronny Martien, M.Si. (2); Prof. Dr.rer.nat. apt. Raden Rara Endang Lukitaningsih, S.Si., M.Si. (3); Prof. Dr. apt. Agung Endro Nugroho, S.Si., M.Si. (4)
Tanggal/Date 2 2018
Kata Kunci/Keyword
Abstrak/Abstract This study aimed to conduct a preparation and characterization of andrographolide isolated from Andrographis paniculata Nees (AND)-loaded Self-Nano Emulsifying Drug Delivery System (SNEDDS) to improve its oral dissolution and bioavailability. The selection of oil, surfactant and co-surfactant components for preliminary screening of self-nano emulsifying formulation was determined by solubility study of AND in various vehicles. Ternary phase diagrams were constructed to identify the nanoemulsification area of the selected systems. The transmittance, droplet size, zeta potential, thermodynamic stability, robustness to dilution, in-vitro release, and oral bioavailability of chosen formulations were investigated. Eight formulations containing Capryol-90, Tween 20 and polyethylene glycol (PEG) 400 were found to be optimal AND-loaded SNEDDS (AND SNEDDS). The robustness to dilution test showed that the formulation containing Capryol-90, Tween 20 and PEG 400 (20: 70: 10 and 20: 60: 20) could be selected for dissolution study. The dissolution study then demonstrated that optimized AND SNEDDS was significantly higher in comparison to that from plain AND. AND SNEDDS showed 1.2 fold enhancement in AUC, 1.26 fold increase in Cmax, and 1.72 fold decrease in Tmax in contrast to plain AND. The results suggested that SNEDDS formulation could enhance the dissolution and the bioavailability of andrographolide isolated from Andrographis paniculata Nees.
Rumpun Ilmu Farmasetika dan Teknologi Farmasi
Bahasa Asli/Original Language Bahasa Indonesia
Level Nasional
Status
Dokumen Karya
No Judul Tipe Dokumen Aksi
1Editorial Board.pdf[PAK] Halaman Editorial
2Halaman sampul.pdf[PAK] Halaman Cover
329_ Naskah Journal of Drug Delivery Science and Technology 2018-Vol 47_p_ 514-520.pdf[PAK] Full Dokumen
4Daftar isi.pdf[PAK] Daftar Isi
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