Non-specific immune potentiating activity of fucoidan from a tropical brown algae (Phaeophyceae), Sargassum cristaefolium in tilapia (Oreochromis niloticus)
Penulis/Author
Prof. Dr. Ir. Alim Isnansetyo, M.Sc. (1); AMIQATUL FIKRIYAH (2); Apt Noer Kasanah, S.Si., M.Si., Ph.D. (3); Prof. Dr. Ir. Murwantoko, M.Si. (4)
Tanggal/Date
2016
Kata Kunci/Keyword
Abstrak/Abstract
Fucoidan mainly produced by brown algae is a sulfated polysaccharide with fucose as a main molecule backbone. The objective of this research was to evaluate the non-specific immune potentiating activity of fucoidan from a tropical brown alga, Sargassum cristaefolium indigenous to the Gunungkidul coast, Yogyakarta, Indonesia. Fucoidan was extracted by acidic extraction, separated from alginate by CaCl2 precipitation and precipitated with ethanol. To know the component of fucoidan, acid hydrolysis was conducted and analyzed by using silica gel thin layer chromatography. In these analyses, a commercial fucoidan from Fucus vesiculosus was used as a standard fucoidan. Fucoidan isolated from S. cristaefolium was composed by monosaccharide components of fucose and galactose. The result revealed that injection of fucoidan increased phagocytic activity, total plasma protein, leukocrit and leukocyte count significantly (p < 0.05). The immunomodulating activity of fucoidan from S. cristaefolium was comparable to that of fucoidan standard from F. vesiculosus. However, administration of fucoidan did not affect the phagocytic index and leukocyte differentiation. Injection of fucoidan from S. cristaefolium effectively increased innate immunity parameters of tilapia at doses of 0.4–0.6 mg/kg fish suggested that this fucoidan was potential use for immunostimulant to control fish diseases.
Rumpun Ilmu
Bioteknologi Perikanan
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
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Article_Non-specificImmunePotentiating.pdf
[PAK] Full Dokumen
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COMPILED AQUACULTURE INTERNAS.pdf
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Similarity_Non-specific immune potentiating activity of fucoidan from a tropical brown algae (Phaeophyceae), Sargassum cristaefolium in tilapia (Oreochromis niloticus).pdf
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Editoriali_Aqua Intl-Fikriyah.pdf
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Cover_Aqua Intl-Fikriyah.pdf
[PAK] Halaman Cover
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Daftar Isi_Aqua Intl-Fikriyah.pdf
[PAK] Daftar Isi
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2016 Non-specific immune potentiating activity of fucoidan.pdf
