NEW HOPE ON DRUG LEADS DEVELOPMENT FROM DEEP
OCEAN: HALOGENATED ALKALOIDS OF AGELAS SPONGES
Penulis/Author
Prof. Dr.rer.nat. apt. Triana Hertiani, S.Si., M.Si. (1)
Tanggal/Date
2014
Kata Kunci/Keyword
Abstrak/Abstract
Agelas sponge is found in abundancy from Indonesia’s
ocean. This sponge produces an important chemotaxonomic group
of compounds, derived from pyrrole-imidazole alkaloids. This group
of compounds is one of those exclusively found from marine
environment. Marine sponges are reported to be promising drug
lead producers having unique chemical structures of which many
have no terrestrial counterparts. The objective of this report is to
give an overview of the reported attempts from up to down stream
to develop pyrrole-imidazole alkaloids as new drug lead. Literatures
up to 2013 reporting this group of compounds from Agelas sponges
were studied. Discussion on the halogenated alkaloids covers the
producers, description of high chemical diversity, identification,
biosynthesis and ecological relevance as well as their role as a
promising drug candidate. Alternatives to provide continous
supplies for drug development are also discussed considering that
wild harvesting of the sponge producers can lead to ecological
damage in the future . Broad range of interesting pharmacological
importance as well as several success in developing synthetic route
for production supports its development as drug candidate.
