Karya
Judul/Title Milk Fermented with Pediococcus acidilactici Strain BE Improves High Blood Glucose Levels and Pancreatic Beta-cell Function in Diabetic Rats
Penulis/Author Prof. Widodo, S.P., M.Sc. Ph.D. (1) ; HANNA RESPATI P K (2); Dr. med. vet. drh. Hevi Wihadmadyatami, M.Sc. (3); Anggi Lukman Wicaksana, S.Kep., Ns., MS. (4)
Tanggal/Date 1 2023
Kata Kunci/Keyword
Abstrak/Abstract This study evaluated the effects of milk fermented with Pediococcus acidilactici strain BE and P. pentosaceus strain M103 on diabetes in rats (Rattus norvegicus). The bacteria were separately used as starter cultures for milk fermentation, and the products were then fed to diabetic rats for 15 days. Blood glucose levels, immunohistochemical and histological indicators, lipid profiles, and total lactic acid bacterium counts were evaluated before and after treatment. The administration of milk fermented with P. acidilactici strain BE reduced blood glucose levels from 410.27 ± 51.60 to 304.07 ± 9.88 mg/dL (p < 0.05), similar to the effects of metformin (from 382.30 ± 13.39 mg/dL to 253.33 ± 40.66 mg/dL, p < 0.05). Increased insulin production was observed in diabetic rats fed milk fermented with P. acidilactici strain BE concomitant with an increased number and percentage area of immunoreactive beta-cells. The structure of insulin-producing beta-cells was improved in diabetic rats fed milk fermented with P. acidilactici strain BE or metformin (insulin receptor substrate scores of 5.33 ± 0.94 and 3.5 ± 0.5, respectively). This suggests that the administration of milk fermented with P. acidilactici BE potentially reduces blood glucose levels and improves pancreatic beta-cell function in diabetic rats.
Rumpun Ilmu Bioteknologi Peternakan
Bahasa Asli/Original Language English
Level Internasional
Status
Dokumen Karya
No Judul Tipe Dokumen Aksi
1Milk Fermented with Pediococcus acidilactici Strain BE Improves High Blood Glucose Levels.pdfDokumen Pendukung Karya Ilmiah (Hibah, Publikasi, Penelitian, Pengabdian)
2Widodo et al_2023_Food Science of Animal Resources 43(1), 2023_170-183.pdf[PAK] Full Dokumen
3Similarity Cek_Milk Fermented.pdf[PAK] Cek Similarity
4Front Matter.pdf[PAK] Full Dokumen