| Penulis/Author |
EFFIKA NURNINGTYAS PUTRI (1); dr. Erika Maharani, Sp.JP(K). (2); Jajah Fachiroh, SP., M.Si., Ph.D. (3); Prof. dr. Fatwa Sari Tetra Dewi, M.P.H., Ph.D (4); dr. Anggoro Budi Hartopo, Sp.PD., M.Sc., Sp.JP., Ph.D (5) |
| Abstrak/Abstract |
Background and Objectives: Metabolic syndrome (MetS) increases the cardiovascular
disease (CVD) risk, including sudden cardiac death. Ventricular repolarization heterogeneity
is a marker of CVD, which can be predicted by 12-lead electrocardiogram (ECG) frontal
QRS-T angle. This study investigated whether MetS and its components are related to
abnormal frontal QRS-T angle.
Methods: We obtained anthropometric measurements, blood samples, and 12-lead ECGs
from adult participants, excluding those with coronary heart disease. MetS was defined as the
presence of 3 of the following 5 components: central obesity, hypertension, diabetes mellitus,
elevated triglyceride, and low high-density lipoprotein cholesterol. Frontal QRS-T angle was
defined as the difference between the QRS and T axes (QRS axis − T axis) and was categorized
as normal (≤90°) or abnormal (>90°).
Results: We enrolled 1,017 participants (mean age, 59±10 years). The prevalence of MetS was
51%, and the main component was hypertension (87.5%). The mean frontal QRS-T angle
did not differ statistically between MetS and non-MetS (29±29° vs. 26±25°, respectively;
p=0.083), and the prevalence of abnormal frontal QRS-T angle was comparable (4.4% vs.
3.6%, respectively; p=0.372). Hypertension (odds ratio [OR], 3.94, 95% confidence interval
[CI], 1.47–11.97, p=0.039) and age ≥60 years (OR, 2.08, 95% CI, 1.80–4.70, p=0.043) were
independent predictors for abnormal frontal QRS-T angle.
Conclusions: Among Indonesians, MetS was not statistically associated with an abnormal frontal QRS-T angle; however, significantly increased odds of abnormal frontal QRS-T angles
were found with hypertension. |
