MARINE RESOURCES COMPOUND WITH MELANOGENIC REGULATORY PROPERTIES: ESPECIALLY SEAGRASS, SEAWEED AND MARINE SPONGE AS AN ANTI-MELANOGENIC ACTIVITY
Penulis/Author
Diah Tri Utami (1); Prof. Dr. apt. Erna Prawita Setyowati, M.Si. (2); Dr.rer.nat. apt. Yosi Bayu Murti, S.Si., M.Si. (3); Prof. Dr. apt. Edy Meiyanto, M.Si. (4)
Tanggal/Date
2024
Kata Kunci/Keyword
Abstrak/Abstract
Tyrosinase is a rate-limiting enzyme that is essential for the synthesis of melanin and controls pigmentation in the skin. The most common strategy in cosmeceutical products for skin lightening is suppression of tyrosinase. Marine substances contain a variety of unique chemical compounds that have the potential to develop into new bioactive compounds as future medications for skin hyperpigmentation therapy. In this review, we summarize 55 compounds from marine resources that have been identified as active in inhibiting the tyrosinase enzyme activity from research studies published up to April 2023. Those substances are classified to be very strong, strong, and moderate inhibit tyrosinase activity and melanin biosynthesis. Based on the IC50 value and the percentage of decreased levels of the tyrosinase enzyme from the extract and the identified bioactive metabolites. There are 12 compounds which act as potential anti-melanogenic agents based on literature studies. Tables 1 present a summary of anti-melanogenic metabolites derived from marine natural products in the form of extracts, fractionates or isolated compounds. We propose to present a new perspective on the discovery of metabolites from seagrasses, seaweeds and marine sponges that can be applied as lead compounds in developing medications for anti-hyperpigmentation therapy through this review.
Rumpun Ilmu
Biologi Farmasi
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
4266_Diah_Japs_pdf.pdf
Bukti Published
2
Submission Confirmation - erna_prawita@ugm_ac_id - Universitas Gadjah Mada Mail.pdf
